The Acid Injury & Repair (AIR) model is an ex vivo platform we established to study lung injury and repair in precision-cut lung slices (PCLS). The model generates a spatially restricted area of acid-induced injury within a lung tissue slice, enabling the cellular and molecular processes underlying tissue damage and repair to be investigated within the native lung microenvironment.
We have established and characterised the AIR model in both mouse and human PCLS, providing a physiologically relevant platform for investigating mechanisms of lung repair and regeneration. The model can be used to study the response of lung tissue to injury, identify mechanisms and therapeutic targets involved in repair, and evaluate potential regenerative medicine strategies and drug candidates.
Our work establishing the AIR model in mouse and human PCLS has been published in Kim et al. 2020 and Bankole et al. 2025., respectively.
We also provide consultancy on the application of the AIR model as a preclinical platform for therapeutic and drug screening, supporting the development and evaluation of novel treatments for lung injury and repair. Learn more about our Imperial Consultants expertise.