Dr Sek Shir Cheong is a postdoctoral research associate. Her research aims to provide insights into molecular mechanisms underlying lung disease. Aberrant lung repair is the hallmark of adult lung diseases, including Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF). By using a combination of molecular and cellular approaches in in vivo and in vitro mouse and human model systems, Sek Shir investigates the retinoic acid and planar cell polarity (PCP) signalling pathways, which are known to play a pivotal role in lung development to identify potential components that can be targeted in novel treatments to promote lung tissue repair.
Cheong, S.S., et al. The planar cell polarity component VANGL2 is a key regulator of mechanosignaling. Frontiers in Cell and Developmental Biology. 2020 Oct 29;8:577201.
Dudakova, L., Tuft, S., Cheong S.S., et al. Novel disease-causing variants and phenotypic features of X-linked megalocornea. Acta Opthalmologica. 2021 doi: 10.1111/aos.15022
Cheong, S.S. & Dean, C.H. On the Move: The commander IL-4 leads the cell army in collective migration. Nov 13, 2018. Am J Respir Cell Mol Biol.
Dudakova, L., Cheong, S.S., et al. Familial limbal stem cell deficiency: clinical, cytological and genetic characterization. Stem Cell Rev. 2018 Feb;14(1):148-151.
Cheong, S.S., Hull, S., et al. Pleiotropic effect of a novel mutation in GCNT2 causing congenital cataract and a rare adult i blood group phenotype. Hum Genome Var. 2017 Feb 16;4:17004.
Cheong, S.S., et al . Mutations in CPAMD8 cause a unique form of autosomal-recessive anterior segment dysgenesis. Am J Hum Genet. 2016 Dec 1;99(6):1338-1352.
Davidson, A.E., Cheong, S.S., et al. Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness. PLoS One. 2014 Aug 5;9(8):e104163.