Dr Cheong is a research associate. Using ex vivo 3D Precision-Cut Lung Slices (mini-lung) and in vitro cell models, her research is focused on delineating the role of Wnt/Planar Cell Polarity and Retinoic Acid signalling in promoting lung repair following injury. She is also currently developing different novel methods of manipulating gene/mRNA in ex vivo human and mouse 3D lung tissues, which have potential to be extended to other organs/systems. In collaboration with Imperial College London Consultants (ICON), Sek-Shir also consults on the application of PCLS Acid Injury Repair (AIR) model that the lab developed for semi-highthroughput pre-clinical drug screening to identify potential targets to repair lung injury.
Publications
Cheong, S.S., et al. The planar cell polarity component VANGL2 is a key regulator of mechanosignaling. Frontiers in Cell and Developmental Biology. 2020 Oct 29;8:577201.
Dudakova, L., Tuft, S., Cheong S.S., et al. Novel disease-causing variants and phenotypic features of X-linked megalocornea. Acta Opthalmologica. 2021 doi: 10.1111/aos.15022
Cheong, S.S. & Dean, C.H. On the Move: The commander IL-4 leads the cell army in collective migration. Nov 13, 2018. Am J Respir Cell Mol Biol.
Dudakova, L., Cheong, S.S., et al. Familial limbal stem cell deficiency: clinical, cytological and genetic characterization. Stem Cell Rev. 2018 Feb;14(1):148-151.
Cheong, S.S., Hull, S., et al. Pleiotropic effect of a novel mutation in GCNT2 causing congenital cataract and a rare adult i blood group phenotype. Hum Genome Var. 2017 Feb 16;4:17004.
Cheong, S.S., et al . Mutations in CPAMD8 cause a unique form of autosomal-recessive anterior segment dysgenesis. Am J Hum Genet. 2016 Dec 1;99(6):1338-1352.
Davidson, A.E., Cheong, S.S., et al. Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness. PLoS One. 2014 Aug 5;9(8):e104163.