Sally Yunsun Kim

Dr. Sally Yunsun Kim is a current recipient of the Wellcome Trust Institutional Strategic Support Fund Springboard Fellowship. Her research is focused on using lung-derived extracellular vesicles as a tool to study altered biology of lung tissue. There are many unknown aspects of tissue-derived extracellular vesicle biology, Sally’s project aims to contribute to the fast-growing knowledge of EVs as non-cellular tissue modifiers. During her previous ERS/EMBO fellowship, she developed an innovative approach to study lung injury and repair using precision-cut lung slices and focused on targeting the Wnt-stimulated Planar Cell Polarity (PCP) pathway, an important signalling pathway in promoting lung repair following injury.

Selected Publications: 

Kim, S.Y., Mongey, R., Wang, P., Rothery, S., Gaboriau, D.C.A., Hind, M., Griffiths, M., Dean, C.H. (2021) The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair. Biomaterials 267:120480.

Kim, S.Y., Mongey, R., Griffiths, M., Hind, M., Dean, C.H. (2020) An ex-vivo acid injury and repair (AIR) model using precision-cut lung slices to understand lung injury and repair. Current Protocols in Mouse Biology 10(4):e85.

Cheong, S.S., Akram, K.M., Matellan, C., Kim, S.Y., Gaboriau, D.C.A., Hind, M., del Río Hernández, A.E., Griffiths, M., Dean, C.H. (2020) The planar cell polarity component VANGL2 is a key regulator of mechanosignaling. Frontiers in Cell and Developmental Biology 8:557201.

Chrzanowski, W., Kim, S.Y., McClements, L. (2020) Can stem cells beat COVID-19: Advancing stem cells and extracellular vesicles toward mainstream medicine for lung injuries associated with SARS-CoV-2 infections. Frontiers in Bioengineering and Biotechnology 8:554.

Kim, S.Y., Khanal, D., Kalionis, B., Chrzanowski, W. (2019) High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy. Nature Protocols 14:576–93.

Kim, S.Y., Joglekar, M.V., Hardikar, A.A., Phan, T.H., Khanal, D., Tharkar, P., Limantoro, C., Johnson, J., Kalionis, B., Chrzanowski, W. (2019) Placenta stem/stromal cell-derived extracellular vesicles for potential use in lung repair. Proteomics 19(17):e1800166.

Kim, S.Y., Khanal, D., Tharkar, P., Kalionis, B., Chrzanowski, W. (2018) None of us is the same as all of us: resolving heterogeneity of extracellular vesicles using single-vesicle, nanoscale characterization with high-resolution resonance enhanced atomic force microscope infrared spectroscopy. Nanoscale Horizons 3:430-8.

Review articles:

Bjørge, I.M.*Kim, S.Y.*, Mano, J.F., Kalionis, B., Chrzanowski, W. Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair. Biomaterials Science 2018, 6(1):60-78. *Equal contribution.

Reczyńska, K.*, Tharkar, P.*Kim, S.Y.*, Wang, Y., Pamuła, E., Chan, H.K., Chrzanowski, W. Animal models of smoke inhalation injury and related acute and chronic lung diseases. Advanced Drug Delivery Reviews, 2018, 123:107-134. *Equal contribution.