Dr. Sally Yunsun Kim is a current recipient of the Wellcome Trust Institutional Strategic Support Fund Springboard Fellowship. Her research is focused on using lung-derived extracellular vesicles as a tool to study altered biology of lung tissue. There are many unknown aspects of tissue-derived extracellular vesicle biology, Sally’s project aims to contribute to the fast-growing knowledge of EVs as non-cellular tissue modifiers. During her previous ERS/EMBO fellowship, she developed an innovative approach to study lung injury and repair using precision-cut lung slices and focused on targeting the Wnt-stimulated Planar Cell Polarity (PCP) pathway, an important signalling pathway in promoting lung repair following injury.
Kim, S.Y., Mongey, R., Wang, P., Rothery, S., Gaboriau, D.C.A., Hind, M., Griffiths, M., Dean, C.H. (2021) The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair. Biomaterials 267:120480.
Kim, S.Y., Mongey, R., Griffiths, M., Hind, M., Dean, C.H. (2020) An ex-vivo acid injury and repair (AIR) model using precision-cut lung slices to understand lung injury and repair. Current Protocols in Mouse Biology 10(4):e85.
Cheong, S.S., Akram, K.M., Matellan, C., Kim, S.Y., Gaboriau, D.C.A., Hind, M., del Río Hernández, A.E., Griffiths, M., Dean, C.H. (2020) The planar cell polarity component VANGL2 is a key regulator of mechanosignaling. Frontiers in Cell and Developmental Biology 8:557201.
Chrzanowski, W., Kim, S.Y., McClements, L. (2020) Can stem cells beat COVID-19: Advancing stem cells and extracellular vesicles toward mainstream medicine for lung injuries associated with SARS-CoV-2 infections. Frontiers in Bioengineering and Biotechnology 8:554.
Kim, S.Y., Khanal, D., Kalionis, B., Chrzanowski, W. (2019) High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy. Nature Protocols 14:576–93.
Kim, S.Y., Joglekar, M.V., Hardikar, A.A., Phan, T.H., Khanal, D., Tharkar, P., Limantoro, C., Johnson, J., Kalionis, B., Chrzanowski, W. (2019) Placenta stem/stromal cell-derived extracellular vesicles for potential use in lung repair. Proteomics 19(17):e1800166.
Kim, S.Y., Khanal, D., Tharkar, P., Kalionis, B., Chrzanowski, W. (2018) None of us is the same as all of us: resolving heterogeneity of extracellular vesicles using single-vesicle, nanoscale characterization with high-resolution resonance enhanced atomic force microscope infrared spectroscopy. Nanoscale Horizons 3:430-8.
Bjørge, I.M.*, Kim, S.Y.*, Mano, J.F., Kalionis, B., Chrzanowski, W. Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair. Biomaterials Science 2018, 6(1):60-78. *Equal contribution.
Reczyńska, K.*, Tharkar, P.*, Kim, S.Y.*, Wang, Y., Pamuła, E., Chan, H.K., Chrzanowski, W. Animal models of smoke inhalation injury and related acute and chronic lung diseases. Advanced Drug Delivery Reviews, 2018, 123:107-134. *Equal contribution.