Identifying novel factors important for the repair of diseases or damaged lungs
Many adult lung diseases involve abnormal tissue repair. These diseases are poorly understood and there is an urgent requirement for treatments. Although once thought to be incapable, recent work has shown that adult lungs are able to repair/regenerate tissue under certain conditions. Our aim is to harness the intrinsic capacity of adult lung cells to repair damaged tissue using several approaches.
Planar cell polarity in organ formation. Henderson DJ, Long DA, Dean CH. Curr Opin Cell Biol. 2018 Jul 13;55:96-103.
Zhang Y, Poobalasingam T, Yates LL, Walker SA, Taylor MS, Chessum L, Harrison J, Tsaprouni L, Adcock IM, Lloyd CM, Cookson WO, Moffatt MF, Dean CH et al., 2018, Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma, DISEASE MODELS & MECHANISMS, Vol: 11, ISSN: 1754-8403
Dean CH, 2014, NORMAL AND ABNORMAL LUNG DEVELOPMENT-RECENT ADVANCES, PEDIATRIC PULMONOLOGY, Vol: 49, Pages: S25-S26, ISSN: 8755-6863
Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CHet al., 2013, Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung, DEVELOPMENTAL BIOLOGY, Vol: 373, Pages: 267-280, ISSN: 0012-1606
Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CHet al., 2010, The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis, HUMAN MOLECULAR GENETICS, Vol: 19, Pages: 2251-2267, ISSN: 0964-6906